Generic Diovan (Valsartan)

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Diovan - General Information:

Diovan (trade name Diovan®) is an angiotensin II receptor antagonist, acting on the AT1 subtype. In the U.S., valsartan is indicated for treatment of high blood pressure, of congestive heart failure (CHF), and post-myocardial infarction (MI). In 2005, Diovan® was prescribed more than 12 million times in the United States.

Pharmacology:

Diovan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Unlike the angiotensin receptor antagonist losartan, Diovan does not have an active metabolite or possess uricosuric effects.
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Diovan for patients

Diovan Interactions

No clinically significant pharmacokinetic interactions were observed when valsartan was coadministered with amlodipine, atenolol, cimetidine, digoxin, furosemide, glyburide, hydrochlorothiazide, or indomethacin. The valsartan-atenolol combination was more antihypertensive than either component, but it did not lower the heart rate more than atenolol alone.

Coadministration of valsartan and warfarin did not change the pharmacokinetics of valsartan or the time-course of the anticoagulant properties of warfarin.

CYP 450 Interactions: The enzyme(s) responsible for valsartan metabolism have not been identified but do not seem to be CYP 450 isozymes. The inhibitory or induction potential of valsartan on CYP 450 is also unknown.

As with other drugs that block angiotensin II or its effects, concomitant use of potassium sparing diuretics (e.g. spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine.

Diovan Contraindications

Diovan^® (valsartan) is contraindicated in patients who are hypersensitive to any component of this product.

Additional information about Diovan

Diovan Indication: For the treatment of hypertension.
Mechanism Of Action: Diovan competes with angiotensin II for binding at the AT₁ receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Valsartan
Synonyms: Not Available
Other Brand Names containing Valsartan: Diovan; Diovan HCT; Valsarran
Dosage Forms of Diovan: Tablet Oral
Capsule Oral
Organisms Affected: Humans and other mammals